pac-genomics-next-generation-sequencing

Next Generation Sequencing

With so many NGS choices today, we offer the platform
with up to 3 million reads per sample

We are excited to offer our innovative Next Generation Sequencing (NGS) platform for aneuploidy. The NGS approach utilizes new genomic technology to generate millions of reads of amplified DNA from embryo biopsy and then align the reads to a known reference genome using bioinformatics.

As leaders in clinical genetics, PacGenomics has customized a platform that is unparalleled by any other PGS lab. Our breakthrough technology enables unmatched quality at the most affordable cost to your patients, with the shortest turnaround time available today.

We use the Illumina NGS platform, but improve upon the existing platform with PacGenomics’ customized library to both reduce cost and provide results with a significant increase in data generated, as compared to existing NGS platforms. NGS assays on the PGS market today typically run 30 cycles of DNA sequencing, generating read lengths of 36 base pairs. The PacGenomics platform runs 150 cycles of DNA sequencing generating read lengths of 75-150 base pairs! Longer reads lead to increased fidelity and confidence in clinical calls, with greater resolution of small segmental imbalances.

Like other PGS labs, we multiplex samples by using a barcoding system, but unlike some labs, we limit our multiplexing, in order to generate one to three million high quality reads per sample. And of course, we do all this after using a best-in-class amplification system, which has been shown to generate the most uniform coverage for NGS platforms.

NGS is quickly becoming the future of PGS, but NGS platforms are not created equal.

The PacGenomics’ Difference

  • Unique, in-house customized platform & library
  • 150 cycles of DNA sequencing, generating read lengths of 75-150 base pairs
    (5x the cycles & 2-4x the read lengths of other platforms on the market)
  • 1-3 million high quality reads per sample
    (2x the reads per sample of other platforms on the market)
  • Best-in-class amplification system to ensure the most uniform coverage
    across the platform
PacGenomics-7957-MiSeq-1-new-generation-sequencing